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Disposable and versatile optical sensors for SERS analysis of liquid samples by fiber-based spectroscopy
Author(s): C. Credi; O. Bibikova; C. Dallari; B. Tiribilli; F. Ratto; S. Centi; R. Pini; V. Artyushenko; R. Cicchi; Francesco S. Pavone
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Paper Abstract

Optical detection techniques based on surface enhanced Raman spectroscopy (SERS) can provide relevant information on molecular and protein composition of biological samples, thus enabling to discriminate between physiological and pathological conditions. With the attempt to develop point-of-impact diagnostics devices, in this study we combine lowcost fabrication processes with surface functionalization strategies for the fabrication of SERS-active polymeric substrates engineered to selectively detect specific biomarkers. By reversibly coupling these devices with the distal end of portable Raman instruments, SERS measurements could be potentially implemented for the early diagnosis of widespread pathologies by SERS analysis of liquid biopsies.

Paper Details

Date Published: 22 July 2019
PDF: 3 pages
Proc. SPIE 11075, Novel Biophotonics Techniques and Applications V, 110750V (22 July 2019); doi: 10.1117/12.2526929
Show Author Affiliations
C. Credi, European Lab. for Non-linear Spectroscopy (Italy)
Univ. of Florence (Italy)
O. Bibikova, art photonics GmbH (Germany)
C. Dallari, European Lab. for Non-linear Spectroscopy (Italy)
B. Tiribilli, Institute for Complex Systems, National Research Council (Italy)
F. Ratto, Institute of Applied Physics "Nello Carrara," National Research Council (Italy)
S. Centi, Institute of Applied Physics "Nello Carrara," National Research Council (Italy)
R. Pini, Institute of Applied Physics "Nello Carrara," National Research Council (Italy)
V. Artyushenko, art photonics GmbH (Germany)
R. Cicchi, European Lab. for Non-linear Spectroscopy (Italy)
National Institute of Optics, National Research Council (Italy)
Francesco S. Pavone, European Lab. for Non-linear Spectroscopy (Italy)
National Institute of Optics, National Research Council (Italy)
Univ. of Florence (Italy)


Published in SPIE Proceedings Vol. 11075:
Novel Biophotonics Techniques and Applications V
Arjen Amelink; Seemantini K. Nadkarni, Editor(s)

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