Share Email Print
cover

Proceedings Paper • new

Time-domain diffuse optical tomography with lp sparsity regularization for thyroid cancer imaging
Author(s): Shinpei Okawa; Tetsuya Mimura; Hiroyuki Fujii; Hiroshi Kawaguchi; Yukari Tanikawa; Manabu Machida; Eiji Okada; Yoko Hoshi
Format Member Price Non-Member Price
PDF $17.00 $21.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Diffuse optical tomography (DOT) images the distribution of the optical properties, such as the absorption and scattering coefficients, via the image reconstruction from the light intensities measured at the surface of the biological medium. The changes in the optical properties reflect the conditions of the tissues. Therefore, DOT image can provide the information which is not obtained from the other modalities and is useful for medical diagnoses. In this study, the application of the DOT to thyroid cancer diagnosis was investigated. The ultrasound technique is usually carried out for the thyroid cancer diagnosis. It is, however, difficult to distinguish follicular carcinoma from adenoma of thyroid. The optical properties may be helpful for the diagnosis. The image reconstruction algorithm employing the regularization minimizing lp-norm (0 < p < 2) of the reconstructed image was developed. The image was reconstructed from the timeresolved measurement data. The numerical simulations of the image reconstruction were tried. The numerical simulation demonstrated that the developed algorithm was able to image the changes in the optical properties in the medium. Additionally, the image reconstruction of the numerical neck phantom was simulated. The thyroid cancer region was reconstructed successfully. It was demonstrated that the developed algorithm had the possibility to image thyroid cancer.

Paper Details

Date Published: 11 July 2019
PDF: 4 pages
Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 1107407 (11 July 2019); doi: 10.1117/12.2526886
Show Author Affiliations
Shinpei Okawa, National Defense Medical College (Japan)
Tetsuya Mimura, Hamamatsu Univ. School of Medicine (Japan)
Hiroyuki Fujii, Hokkaido Univ. (Japan)
Hiroshi Kawaguchi, National Institute of Advanced Industrial Science and Technology (Japan)
Yukari Tanikawa, National Institute of Advanced Industrial Science and Technology (Japan)
Manabu Machida, Hamamatsu Univ. School of Medicine (Japan)
Eiji Okada, Keio Univ. (Japan)
Yoko Hoshi, Hamamatsu Univ. School of Medicine (Japan)


Published in SPIE Proceedings Vol. 11074:
Diffuse Optical Spectroscopy and Imaging VII
Hamid Dehghani; Heidrun Wabnitz, Editor(s)

© SPIE. Terms of Use
Back to Top