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Short and mid-term reproducibility analysis of cerebral tissue saturation measured by time domain-NIRS
Author(s): F. Lange; I. Tachtsidis
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Paper Abstract

The short- (i.e. over minutes) and mid-term (i.e. over days/weeks) reproducibility of cerebral tissue saturation measured by time domain-NIRS (TD-NIRS) is investigated in this work. We present a pilot study that assess the reproducibility of the measurement of the tissue saturation (StO2) of the prefrontal cortex on a sample of 7 healthy adult volunteers. TDNIRS measurements were acquired at 16 wavelengths, from 780 to 870 nm, in steps of 6 nm, and were fitted with the diffusion model for semi-infinite homogenous media. Then the absolute concentration of oxy- and deoxyhemoglobin ([HbO2], [HHb]) were calculated using Beer-Lambert’s law, in order to calculate the volunteer’s brain tissue saturation (StO2 = [HbO2]/([HbO2]+[HHb])). Three measurement sessions were performed on three different days (within a week interval) to evaluate the mid-term reproducibility of the StO2. For each session, three measurements were taken (within 10 minutes, with repositioning of the probes) to evaluate the short-term reproducibility of the StO2. The reproducibility was expressed as the within-volunteer standard deviation (SDw), calculated using a one-way repeated-measure ANOVA. The SDw in session 1, 2 and 3 were 0.89%, 1.10% and 0.82% respectively, showing a good short-term reproducibility, and the SDw for all 3 sessions was 1.43%, showing a good mid-term reproducibility without significant variations in the StO2 between the 3 sessions. Moreover, the mean ± SD global values of StO2 over all the measurements (n=63) is 62.8+/- 4.2% which is close to the values reported in the literature for adults.

Paper Details

Date Published: 11 July 2019
PDF: 3 pages
Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 110740V (11 July 2019); doi: 10.1117/12.2526780
Show Author Affiliations
F. Lange, Univ. College London (United Kingdom)
I. Tachtsidis, Univ. College London (United Kingdom)


Published in SPIE Proceedings Vol. 11074:
Diffuse Optical Spectroscopy and Imaging VII
Hamid Dehghani; Heidrun Wabnitz, Editor(s)

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