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K-edge subtraction imaging for angiography at a compact synchrotron source
Author(s): Stephanie Kulpe; Martin Dierolf; Eva-Maria Braig; Benedikt Günther; Klaus Achterhold; Bernhard Gleich; Julia Herzen; Ernst Rummeny; Franz Pfeiffer; Daniela Pfeiffer
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Paper Abstract

About one third of all deaths worldwide can be traced back to some form of cardiovascular disease. The gold standard for the diagnosis and interventional treatment of blood vessels is digital subtraction angiography (DSA). An alternative to DSA is K-edge subtraction (KES) imaging, which has been shown to be advantageous for moving organs and to eliminate image artifacts caused by patient movement. As highly brilliant, monochromatic X-rays are required for this method, it has been limited to synchrotron facilities so far, restraining the applicability in clinical routine. Over the past decades, compact synchrotron X-ray sources based on inverse Compton scattering have been evolving, which provide X-rays with sufficient brilliance and that meet spatial and financial requirements affordable in laboratory settings or for university hospitals. In this study, we demonstrate a proofof-principle KES imaging experiment using the Munich Compact Light Source (MuCLS), the first user-dedicated installation of a compact synchrotron X-ray source worldwide. It is shown that the proposed filter-based KES method allows for iodine-contrast agent and calcium to be clearly separated, thereby providing X-ray images only showing one of the two materials. The results show that the quasi-monochromatic spectrum of the MuCLS enables filter-based K-edge subtraction imaging and can become an important tool in pre-clinical research and possible future clinical diagnostics.

Paper Details

Date Published: 9 September 2019
PDF: 12 pages
Proc. SPIE 11110, Advances in Laboratory-based X-Ray Sources, Optics, and Applications VII, 111100J (9 September 2019); doi: 10.1117/12.2526771
Show Author Affiliations
Stephanie Kulpe, Technische Univ. München (Germany)
Martin Dierolf, Technische Univ. München (Germany)
Eva-Maria Braig, Technische Univ. München (Germany)
Benedikt Günther, Technische Univ. München (Germany)
Klaus Achterhold, Technische Univ. München (Germany)
Bernhard Gleich, Technische Univ. München (Germany)
Julia Herzen, Technische Univ. München (Germany)
Ernst Rummeny, Munich School of Medicine, Klinikum rechts der Isar (Germany)
Franz Pfeiffer, Technische Univ. München (Germany)
Munich School of Medicine, Klinikum rechts der Isar (Germany)
Daniela Pfeiffer, Munich School of Medicine, Klinikum rechts der Isar (Germany)


Published in SPIE Proceedings Vol. 11110:
Advances in Laboratory-based X-Ray Sources, Optics, and Applications VII
Alex Murokh; Daniele Spiga, Editor(s)

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