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Cross-polarization OCT needle probe for combined blood vessels detection and tissue differentiation during stereotactic biopsy of brain tumors
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Paper Abstract

An introduction of innovative minimally invasive methods like multimodal optical coherence tomography (OCT) with polarization-sensitivity and angiography modes for intrasurgical guidance appears to be a critical challenge for the modern neurooncology. This study aimed to develop a new instrument for targeted stereotactic brain biopsy based on cross-polarization (CP) OCT realized in standard biopsy needle to increase the safety of ongoing neurosurgical procedures. Experimental studies in vivo on the healthy rat’s brain allow detecting blood vessels in the process of moving the biopsy needle along the brain surface and detect tissue type (cerebral cortex or white matter) when the needle went inside the brain. The images was assessed by visual criteria. However, CP OCT signal quantification methods will increase the sensitivity/specificity for the tissue type differentiation and blood vessels detection. The potential of CP OCT as an effective instrument for OCT-guided stereotactic biopsy of brain tumors was demonstrated.

Paper Details

Date Published: 22 July 2019
PDF: 3 pages
Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 110791D (22 July 2019); doi: 10.1117/12.2526770
Show Author Affiliations
Elena B. Kiseleva, Privolzhsky Research Medical Univ. (Russian Federation)
Pavel A. Shilyagin, Institute of Applied Physics (Russian Federation)
Vladimir N. Romashov, Institute of Applied Physics (Russian Federation)
Yulia V. Korzhimanova, Privolzhsky Research Medical Univ. (Russian Federation)
Marina A. Sirotkina, Privolzhsky Research Medical Univ. (Russian Federation)
Konstantin S. Yashin, Privolzhsky Research Medical Univ. (Russian Federation)
Elena V. Zagaynova, Privolzhsky Research Medical Univ. (Russian Federation)
Grigory V. Gelikonov, Institute of Applied Physics (Russian Federation)
Natalia D. Gladkova, Privolzhsky Research Medical Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 11079:
Medical Laser Applications and Laser-Tissue Interactions IX
Lothar D. Lilge; Carsten M. Philipp, Editor(s)

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