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Optical coherence tomography controlled selective retina therapy with a novel microsecond laser
Author(s): Christian Burri; Alessa Hutfilz; Lorenz Grimm; Patrik Arnold; Andreas Ebneter; Ralf Brinkmann; Dirk Theisen-Kunde; Boris Považay; Christoph Meier
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Paper Abstract

Selective retina therapy (SRT) is a short pulse (μs-regime) alternative to conventional laser photocoagulation (LPC) for treatment of retinal diseases. LPC leads to collateral damage of retinal layers adjacent to the retinal pigment epithelium (RPE), including healthy, non-regenerative photoreceptors due to the high thermal load, whereas in SRT, RPE cells are destroyed by microbubbles without damaging the neuronal retina. A novel experimental SRT laser operating at 532 nm wavelength can deliver 2 – 20 μs pulse sequences. Its tight integration into an upgraded diagnostic SPECTRALIS system combines beam control for treatment planning with real-time optical coherence tomography (OCT) overexposure protection of the photoreceptors. This “Spectralis Centaurus” system, was built and preliminary tested on porcine ex-vivo samples, reaching an unprecedented accuracy with unique planning and follow-up capabilities for upcoming clinical cellular level micro-surgery. The combination of OCT with SRT selectively limits cell death to the RPE by precisely controlling energy deposition while optically monitoring tissue response.

Paper Details

Date Published: 22 July 2019
PDF: 6 pages
Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 1107903 (22 July 2019); doi: 10.1117/12.2526720
Show Author Affiliations
Christian Burri, Berner Fachhochschule Technik und Informatik (Switzerland)
Alessa Hutfilz, Medizinisches Laserzentrum Lübeck GmbH (Germany)
Lorenz Grimm, Berner Fachhochschule Technik und Informatik (Switzerland)
Patrik Arnold, Berner Fachhochschule Technik und Informatik (Switzerland)
Andreas Ebneter, Universitätsklinik für Augenheilkunde, Inselspital (Switzerland)
Ralf Brinkmann, Medizinisches Laserzentrum Lübeck GmbH (Germany)
Dirk Theisen-Kunde, Medizinisches Laserzentrum Lübeck GmbH (Germany)
Boris Považay, Berner Fachhochschule Technik und Informatik (Switzerland)
Christoph Meier, Berner Fachhochschule Technik und Informatik (Switzerland)


Published in SPIE Proceedings Vol. 11079:
Medical Laser Applications and Laser-Tissue Interactions IX
Lothar D. Lilge; Carsten M. Philipp, Editor(s)

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