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Label-free tumor detection with active infrared thermal laparoscopic system in a mouse tumor model
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Paper Abstract

While passive thermal imaging of temperature difference between tumor and neighboring tissue provides limited contrast, active infrared thermal imaging with external heating or cooling may provide a unique contrast mechanism due to distinct thermal responses of tumor from neighboring tissue. We previously developed an active thermo-modulation imaging method with physiologically relevant parameters including the rate of temperature change and thermal relaxation time for tumor detection. Different from conventional passive thermal imaging, active thermo-modulation provides a contrast factor which is the average rate temperature change between tumor and neighboring tissue. With the tumors, the average rate of temperature change was higher than that of neighboring tissue with heating and cooling modulation. For endoscopic infrared thermal imaging, anti-reflection germanium lenses are tested as they have higher reflected indices and transmittance at mid-infrared spectrum. Combined with thermo-modulation, the newly developed infrared endoscopy can advance label-free non-invasive endoscopic screening.

Paper Details

Date Published: 19 July 2019
PDF: 4 pages
Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II, 110731D (19 July 2019); doi: 10.1117/12.2526678
Show Author Affiliations
Gyungseok Oh, Gwangju Institute of Science and Technology (Korea, Republic of)
Euiheon Chung, Gwangju Institute of Science and Technology (Korea, Republic of)


Published in SPIE Proceedings Vol. 11073:
Clinical and Preclinical Optical Diagnostics II
J. Quincy Brown; Ton G. van Leeuwen, Editor(s)

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