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Spectral approach to time domain diffuse optical tomography for breast cancer: validation on meat phantoms
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Paper Abstract

Time Domain Diffuse Optical Tomography (TD-DOT) performed at multiple wavelengths can be used to non-invasively probe tissue composition. Then, tissue composition can be related to breast tissue and lesion type. Thus, TD-DOT could be used for therapy monitoring for breast cancer. We developed a software tool for multi-wavelength TD-DOT and performed a validation on meat phantoms to mimic tissue heterogeneity. An inclusion of different meat was exploited to mimic the presence of a lesion in the breast. Results show good localization of the inclusion, but poor quantification of the reconstructed breast composition. The use of a morphological prior constraint, providing information on inclusion geometry and position, significantly improves both localization and composition estimate.

Paper Details

Date Published: 11 July 2019
PDF: 3 pages
Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 1107408 (11 July 2019); doi: 10.1117/12.2526649
Show Author Affiliations
Edoardo Ferocino, Politecnico di Milano (Italy)
Giuseppe Di Sciacca, Univ. College London (United Kingdom)
Laura Di Sieno, Politecnico di Milano (Italy)
Alberto Dalla Mora, Politecnico di Milano (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)
CNR-Istituto di Fotonica e Nanotecnologie (Italy)
Simon Arridge, Univ. College London (United Kingdom)
Fabrizio Martelli, Univ. degli Studi di Firenze (Italy)
Paola Taroni, Politecnico di Milano (Italy)
CNR-Istituto di Fotonica e Nanotecnologie (Italy)
Andrea Farina, CNR-Istituto di Fotonica e Nanotecnologie (Italy)


Published in SPIE Proceedings Vol. 11074:
Diffuse Optical Spectroscopy and Imaging VII
Hamid Dehghani; Heidrun Wabnitz, Editor(s)

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