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Optical radiomic signatures derived from OCT images to improve identification of melanoma
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Paper Abstract

Malignant melanoma is by far the most dangerous type of skin cancer. Currently, the gold standard to diagnose melanoma in the clinic is excisional biopsy and histopathologic analysis. Approximately 15-30 benign lesions are biopsied to diagnose each melanoma. Additionally, biopsies are invasive and result in pain, anxiety, scarring and disfigurement of patients, and they can be a financial burden to the health care system. Among several imaging techniques developed to enhance melanoma diagnosis, optical coherence tomography (OCT) with its high-resolution and intermediate penetration depth can potentially provide required diagnostic information, noninvasively. We propose an image analysis algorithm, ‘optical properties extraction (OPE)’ that drastically improves the specificity and sensitivity of OCT by identifying unique optical radiomic signatures pertinent to melanoma detection. We evaluate the performance of the algorithm using several tissue-mimicking phantoms. We then test the OPE algorithm with sixty-nine human subjects and demonstrate that melanoma can be differentiated from benign nevi with 97% sensitivity, and 98% specificity.

Paper Details

Date Published: 19 July 2019
PDF: 4 pages
Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110780O (19 July 2019); doi: 10.1117/12.2526624
Show Author Affiliations
Zahra Turani, Sharif Univ. of Technology (Iran, Islamic Republic of)
Wayne State Univ. (United States)
Emad Fatemizadeh, Sharif Univ. of Technology (Iran, Islamic Republic of)
Tatiana Blumetti, A.C. Camargo Cancer Ctr. (Brazil)
Steven Daveluy, Wayne State Univ. (United States)
Ana Flavia Moraes, A.C. Camargo Cancer Ctr. (Brazil)
Wei Chen, Karmanos Cancer Institute (United States)
Darius Mehregan, Wayne State Univ. (United States)
Peter E. Andersen, Technical Univ. of Denmark (Denmark)
Mohammadreza Nasiriavanaki, Wayne State Univ. (United States)
Karmanos Cancer Institute (United States)


Published in SPIE Proceedings Vol. 11078:
Optical Coherence Imaging Techniques and Imaging in Scattering Media III
Maciej Wojtkowski; Stephen A. Boppart; Wang-Yuhl Oh, Editor(s)

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