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Preliminaries results of clinical study of condylomas acuminate using PDT with new illumination devices (Conference Presentation)
Author(s): Hilde H. Buzzá; Mirian D. Stringasci; Cynthia A. Castro; Rita R. H. Crestana; Vanderlei S. Bagnato; Natalia M. Inada

Paper Abstract

It is estimated that up to 75% of the sexually active population is infected with this human papillomavirus virus (HPV). Condylomas acuminate are benign lesions caused by this virus. This study aims to compare photodynamic therapy (PDT) and administration of 70% trichloroacetic acid (TAA) in the condylomas. Each patient is treated weekly until total removal of the lesions, with one of treatment options. In the patients treated with PDT, a Brazilian 20% methyl aminulevulinate cream were applied in the region and incubated by 3 hours and the lesions were illuminated with the CERCa®. This Brazilian system is composed of LEDs emitting at 630 nm which was initially designed for the treatment of cervical intraepithelial neoplasia (CIN) and this study showed the need to develop new devices for illumination of the anus-genital region. During the illumination, a total dose of 150 J/cm2 is delivered over 21 minutes. 22 patients have participated of this clinical study, totaling 15 patients treated with TAA and 8 with PDT, with a complete treatment for 33% using TAA and 75% for PDT. Besides the results of complete response, it is important to highlight that 2 patients showed recurrence for TAA and 4 patients discontinued the treatment with TAA, while, for PDT, there were no cases both recurrence and withdrawal. Therefore, besides the preliminary results obtained with this project show that PDT has been more effective than TAA, it was possible to plan and develop new equipment to ensure greater range of light.

Paper Details

Date Published: 14 August 2019
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Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 1107029 (14 August 2019); doi: 10.1117/12.2526160
Show Author Affiliations
Hilde H. Buzzá, Univ. de São Paulo (Brazil)
Mirian D. Stringasci, Univ. de São Paulo (Brazil)
Cynthia A. Castro, Univ. Federal de São Carlos (Brazil)
Rita R. H. Crestana, Univ. de São Paulo (Brazil)
Vanderlei S. Bagnato, Univ. de São Paulo (Brazil)
Natalia M. Inada, Univ. de São Paulo (Brazil)


Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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