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Characterization of modified agave fructans used as drug carriers to the colon by spectroscopy techniques
Author(s): Carmen Miramontes-Corona; Marco A. Escalante; Ezequiel Delgado; Rosa I. Corona-González; Humberto Vázquez-Torres; Guillermo Toriz
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Paper Abstract

Carbohydrate polymers based on fructose from Agave tequilana Weber var. azul, known as fructans, have a great potential as carriers of drugs due to their chemical structure, which makes them non degradable in the upper digestive tract, but enzymatically degradable in the colon. However, esterification is necessary to obtain hydrophobic compounds capable to preserve drugs at stomach conditions. We esterified fructans with acetyl, lauroyl and palmitoyl moieties for encapsulating ibuprofen as a model drug. Esterification of fructan was confirmed using attenuated total reflectance infrared spectroscopy (ATR-FTIR), while the degree of substitution (DS) was quantified by proton nuclear magnetic resonance (1H-NMR).

Paper Details

Date Published: 9 September 2019
PDF: 7 pages
Proc. SPIE 11128, Infrared Remote Sensing and Instrumentation XXVII, 111280X (9 September 2019); doi: 10.1117/12.2526135
Show Author Affiliations
Carmen Miramontes-Corona, Univ. de Guadalajara (Mexico)
Marco A. Escalante, Univ. de Guadalajara (Mexico)
Ezequiel Delgado, Univ. de Guadalajara (Mexico)
Rosa I. Corona-González, Univ. de Guadalajara (Mexico)
Humberto Vázquez-Torres, Univ. Autónoma Metropolitana-Unidad Iztapalapa (Mexico)
Guillermo Toriz, Univ. de Guadalajara (Mexico)


Published in SPIE Proceedings Vol. 11128:
Infrared Remote Sensing and Instrumentation XXVII
Marija Strojnik; Gabriele E. Arnold, Editor(s)

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