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Nano-biosensors based on dynamic light scattering
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Paper Abstract

The two new approaches to dynamic light scattering (DLS) biosensing are presented. The first method based on the effect of the slowing-down of nanoparticles rotational diffusion due aggregation and the high sensitivity of the autocorrelation function (ACF) of depolarized component of the scattered light to the rotational diffusion coefficient. This way it is possible to significantly increase the sensitivity of the analysis. The second approach implements a competitive immunoassay in the DLS version, while increasing the analyte concentration reduces the degree of aggregation of the conjugates therefore leads to a decrease in the average hydrodynamic diameter. On the basis of the proposed approaches, nanosensors for the PSA tumor marker and the antibiotic cloramphenicol were developed.

Paper Details

Date Published: 21 June 2019
PDF: 11 pages
Proc. SPIE 11060, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials IV, 110600Y (21 June 2019); doi: 10.1117/12.2526055
Show Author Affiliations
Alexander D. Levin, The All-Russian Research Institute for Optical and Physical Measurements (Russian Federation)
Maxim P. Nikitin, Moscow Institute of Physics and Technology (Russian Federation)
Mikhail K. Alenichev, The All-Russian Research Institute for Optical and Physical Measurements (Russian Federation)
Ekaterina B. Drozhzhennikova, The All-Russian Research Institute for Optical and Physical Measurements (Russian Federation)
Vitaly G. Grigorenko, M.V. Lomonosov Moscow State Univ. (Russian Federation)
Alina S. Ringaci, Moscow Institute of Physics and Technology (Russian Federation)
Irina P. Andreeva, M.V. Lomonosov Moscow State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 11060:
Optical Methods for Inspection, Characterization, and Imaging of Biomaterials IV
Pietro Ferraro; Simonetta Grilli; Monika Ritsch-Marte; Christoph K. Hitzenberger, Editor(s)

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