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Targeted PDT-based combinations for cancer: sub-cellular sites and cytotoxic mechanisms (Conference Presentation)

Paper Abstract

Exploiting differences in photosensitizer (PS) localization and mechanisms of action with sequential or simultaneous activation protocols has been shown to improve photodynamic therapy (PDT) efficacy. Various sub-cellular, cellular and stromal components can be targeted, causing selective photodamage. Previous reports have shown that rationally targeting non-overlapping tumor compartments or sub-cellular sites considerably enhances outcomes from PDT. The current presentation describes the benefits of simultaneously targeting lysosomes and mitochondria/endoplasmic reticulum using lipid-anchored and entrapped liposomal preparations of benzoporphyrin derivative, respectively, with an emphasis on results in 3D models of ovarian cancer.

Paper Details

Date Published: 14 August 2019
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Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110702D (14 August 2019); doi: 10.1117/12.2525889
Show Author Affiliations
Imran Rizvi, The Univ. of North Carolina at Chapel Hill (United States)
North Carolina State Univ. (United States)
Girgis Obaid, Wellman Ctr. for Photomedicine (United States)
Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Shubhankar Nath, Wellman Ctr. for Photomedicine (United States)
Massachusetts General Hospital (United States)
Mustafa K. Ruhi, Wellman Ctr. for Photomedicine (United States)
Bogaziçi Üniv. (Turkey)
Kaitlin Moore, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Norteastern Univ. (United States)
Shazia Bano, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
David Kessel, Wayne State Univ. (United States)
Tayyaba Hasan, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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