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Design and evaluation of applicators for photodynamic therapy of oral cavity tumors in low resource settings (Conference Presentation)

Paper Abstract

Oral cancer represents over 30% of cancers reported in low middle-income countries (LMIC), like India and is the leading cause of cancer death among Indian men. Surgery, radiation and chemo therapies are the mainstay of management but are either too expensive, unavailable for people or have extensive side effects. An alternate effective therapy for oral cancer is photodynamic therapy (PDT), a light based spatially targeted cytotoxic therapy that has shown excellent healing of the oral mucosa post treatment. We here combined engineering, optics and biochemistry to produce a low-cost, mobile LED-based light source with 3D printed light applicators for smart phone-based, image-guided PDT. After validating the devices in preclinical models, we performed an ergonomics study on 10 healthy volunteers at the MGH, where the comfort level of the applicators (anterior buccal cheek, posterior buccal cheek and retromolar positions) and presence of fatigue or numbness in the mouth due to the applicators was evaluated. We found that the retromolar and posterior applicators were the most comfortable and well tolerated. After these initial steps, the device was tested in clinical studies of early oral cancer in India. We observe in subjects with T1N0M0 oral lesions that our applicator and light system combination delivered light to cover the entire lesion area and yielded effective PDT response. Of the 18 treatments so far, 14 subjects have responded, with no residual/recurrent disease in follow-up biopsy. The significance of this work is that it offers an alternative treatment modality for early disease without associated morbidities.

Paper Details

Date Published: 14 August 2019
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Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 11070BH (14 August 2019); doi: 10.1117/12.2525860
Show Author Affiliations
Amjad P. Khan, Wellman Ctr. for Photomedicine (United States)
Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Srivalleesha Mallidi, Wellman Ctr. for Photomedicine (United States)
Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Hui Liu, Univ. of Massachusetts Boston (United States)
Liam Daly, Univ. of Massachusetts Boston (United States)
Grant Rudd, Univ. of Massachusetts Boston (United States)
M. A. Bilal Hussain, Jawaharlal Nehru Medical College (India)
Shakir Khan, Jawaharlal Nehru Medical College (India)
Shahid A. Siddiqui, Jawaharlal Nehru Medical College (India)
Syed A. Hasan, Jawaharlal Nehru Medical College (India)
Kafil Akhtar, Jawaharlal Nehru Medical College (India)
Shaista Siddiqui, Jawaharlal Nehru Medical College (India)
Meredith August, Massachusetts General Hospital (United States)
Maria Troulis, Massachusetts General Hospital (United States)
Filip Cuckov, Univ. of Massachusetts Boston (United States)
Jonathan P. Celli, Univ. of Massachusetts Boston (United States)
Tayyaba Hasan, Wellman Ctr. for Photomedicine (United States)
Massachusetts General Hospital (United States)
Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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