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Reactive oxygen species explicit dosimetry for Photofrin-mediated pleural photodynamic therapy
Author(s): Yi Hong Ong; Michele M. Kim; Andrea Dimofte; Arjun G. Yodh; Sunil Singhal; Keith Cengel; Theresa M. Busch; Timothy C. Zhu
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Paper Abstract

Reactive oxygen species explicit dosimetry (ROSED) has been recently developed and demonstrated to be able to better correlate with treatment outcome in both preclinical type I and type II PDT. ROSED involves direct measurements of in-vivo light fluence (rate), invivo photosensitizer concentration and tissue oxygenation to calculate for reacted ROS concentration ([ROS]rx) generated by PDT processes. In this study, we demonstrated ROSED in an ongoing Phase II clinical trial of Photofrin-mediated PDT for pleural mesothelioma [1]. We measured light fluence rate and PS concentration using isotropic detectors and tissue blood flow using DCS contact probes that are sutured on the pleural cavity wall. 7 patients were measured during the period of 2016-2018, which includes 2 patients with one DCS measurement location and 5 patients with two DCS measurements on different locations on the pleural cavity wall. Different dose metrics, including light fluence, PDT dose and [ROS]rx calculated based on light fluence, photosensitizer concentration, and blood flow were compared.

Paper Details

Date Published: 7 August 2019
PDF: 1 pages
Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 11070B0 (7 August 2019); doi: 10.1117/12.2525619
Show Author Affiliations
Yi Hong Ong, Univ. of Pennsylvania (United States)
Michele M. Kim, Univ. of Pennsylvania (United States)
Andrea Dimofte, Univ. of Pennsylvania (United States)
Arjun G. Yodh, Univ. of Pennsylvania (United States)
Sunil Singhal, Univ. of Pennsylvania (United States)
Keith Cengel, Univ. of Pennsylvania (United States)
Theresa M. Busch, Univ. of Pennsylvania (United States)
Timothy C. Zhu, Univ. of Pennsylvania (United States)


Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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