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The benefits of targeted endoscopic biopsy performed using the autofluorescence based diagnostic technique in gastrointestinal tumors
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Paper Abstract

Background and objective The search for new diagnostic and therapeutic procedures is an essential task in contemporary oncology. The purpose of our study was the evaluation of the practical usefulness of endoscopic autofluorescence assessment (AFE) using the Onco-LIFE system, and the estimation of the correlation between the histopathological evaluation with the degree of lesions’ Numerical Color Value (NCV index) and the method’s sensitivity and specificity valuation. Material 67 patients were analyzed and had previously a tumor of the gastrointestinal tract which appeared malignant, but without histopathological confirmation. We measured NCV, estimated the correlation of the clinical diagnosis based on histopathological evaluation with the degree of NCV index from gastrointestinal lesions, and calculated the sensitivity and specificity of this method. Results In the group of 67 patients, we found 44 cases of primary or secondary cancers and 7 cases of non-epithelial malignancies. In this group (51 patients) we identified 13 colorectal cancers and 38 upper gastrointestinal cancers. Based on the NCV index at NCV>1.0, we can show that the sensitivity for malignant neoplastic lesions was 100% and the specificity was 73%, while for NCV>1.5, the sensitivity for malignant neoplastic lesions was 86% and the specificity 100%. Conclusion AFE using the Onco-LIFE system is a helpful tool to perform targeted biopsies at the outset. A significant correlation was found between lesions’ NCV index and the grade of dysplasia or tumor malignancy. AFE sensitivity and specificity is higher than WLE. Further studies are needed, especially performed by expert endoscopists.

Paper Details

Date Published: 7 August 2019
PDF: 1 pages
Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 11070B2 (7 August 2019); doi: 10.1117/12.2525527
Show Author Affiliations
Wojciech Latos, Medical Univ. of Silesia (Poland)
Aleksander Sieroń, Jan Dlugosz Univ. in Czestochowa (Poland)
Grzegorz Cieślar, Medical Univ. of Silesia (Poland)
Aleksandra Kawczyk-Krupka, Medical Univ. of Silesia (Poland)


Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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