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In vivo optical clearing of human skin under the effect of aqueous solutions of some monosaccharides
Author(s): K. V. Berezin; K. N. Dvoretsky; M. L. Chernavina; V. V. Nechaev; A. M. Lichter; V. V. Smirnov; E. M. Antonova; O. N. Grechukhina; M. V. Kartashov; V. V. Tuchin
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Paper Abstract

The results of in vivo optical immersion clearing of human skin under the effect of aqueous solutions of some immersion agents (monosaccharides of ribose, glucose and fructose, as well as glycerol, a triatomic alcohol) were obtained with the use of the OCT method. Values of average velocity of scattering coefficient change, obtained through an averaged Ascan of the OCT signal in the region of derma with the depth of 350 to 700 μm, were determined to evaluate the optical clearing efficiency. The velocity of scattering coefficient change and the optical clearing potential value appeared to be well correlated. The complex molecular modeling of a number of immersion clearing agents with a mimetic peptide of collagen (GPH)3, carried out with the use of the methods of classical molecular dynamics and quantum chemistry, allowed to identify correlations between the optical clearing efficiency and such a property as the energy of intermolecular interaction of clearing agents with a collagen peptide fragment.

Paper Details

Date Published: 3 June 2019
PDF: 8 pages
Proc. SPIE 11066, Saratov Fall Meeting 2018: Laser Physics, Photonic Technologies, and Molecular Modeling, 110661D (3 June 2019); doi: 10.1117/12.2523317
Show Author Affiliations
K. V. Berezin, Saratov State Univ. (Russian Federation)
K. N. Dvoretsky, Saratov State Medical Univ. (Russian Federation)
M. L. Chernavina, Saratov State Univ. (Russian Federation)
V. V. Nechaev, Saratov State Technical Univ. (Russian Federation)
A. M. Lichter, Astrakhan State Univ. (Russian Federation)
V. V. Smirnov, Astrakhan State Univ. (Russian Federation)
E. M. Antonova, Astrakhan State Medical Univ. (Russian Federation)
O. N. Grechukhina, Caspian Univ. of Maritime and River Transport (Russian Federation)
M. V. Kartashov, Caspian Univ. of Maritime and River Transport (Russian Federation)
V. V. Tuchin, Saratov State Univ. (Russian Federation)
Astrakhan State Univ. (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 11066:
Saratov Fall Meeting 2018: Laser Physics, Photonic Technologies, and Molecular Modeling
Vladimir L. Derbov, Editor(s)

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