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Computational study of endothelial-mediated vascular responses at Y-bifurcation: when occlusion does not reduce the total flow
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Paper Abstract

While vasoreactivity of an individual blood vessel is quite well studied, much less in known about stimulustriggered behavior of microcirculatory networks in situ . the available experimental data on topic suggest that the response pattern of the network, being the coordinated change of flow through the group of vessel, asa well as adjusment of their diameters, ofthen can be found inconsistent with what is expected from ”system of elastic tubes”. Physiologically, this is because of autoregulation of vascular tone by means of number of pathways, mediated by cells that form two main cellular layers - the endothelial cells and the vascular smooth muscle cells. Since it is still not easy to measure simulteneously bothe the flow/ diameter and the degree of activation of smooth muscle cells, the mathematical modeling study on topic is very suitable. In this work we present the results of modeling study performed on the set of 20 different variants of 14-vessels vascular tree. Our results show three distinctive stages of vascular response to the abrupt change of conditions (occlusion of one of vessels).

Paper Details

Date Published: 3 June 2019
PDF: 8 pages
Proc. SPIE 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 1106714 (3 June 2019); doi: 10.1117/12.2523312
Show Author Affiliations
Yuri N. Avtomonov, Saratov State Univ. (Russian Federation)
Elena S. Stiukhina, Saratov State Univ. (Russian Federation)
Dmitry E. Postnov, Saratov State Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 11067:
Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions
Dmitry Engelevich Postnov, Editor(s)

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