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Optical diagnostics of bile duct tissues state with tumor compression
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Paper Abstract

The paper presents the results of in vivo experimental measurements of the endogenous fluorescence and blood perfusion in common bile duct tissues in obstructive jaundice patients during minimally invasive surgical operations. Nowadays the type of interventions become more widespread for treating hepatopancreatobiliary pathologies. An effective feedback which can be established by one or more optical diagnostic channels integrated into the standard instruments for minimally invasive manipulations would be of particular value to practical surgeons. To collect reference data, an experimental study has been conducted using a fiber optical probe with fluorescence spectroscopy and laser Doppler flowmetry channels. For every measurement, the areas of interest were different areas of common bile duct obstructed by a malignant tumor. Obtained results demonstrated significant variety registered intensities of fluorescence spectra and values of blood perfusion. Tested fiber optical endoscopic system showed sensitivity to the tissue state in the investigated area, so the two modal approach seems to be promising for further research and implementation in clinical practice.

Paper Details

Date Published: 3 June 2019
PDF: 7 pages
Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 1106508 (3 June 2019); doi: 10.1117/12.2522670
Show Author Affiliations
Ksenia Y. Kandurova, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Viktor V. Dremin, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Evgeny A. Zherebtsov, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Univ. of Oulu (Finland)
Elena V. Potapova, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Mariya A. Filina, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Andrey V. Dunaev, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Andrian V. Mamoshin, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Orel Regional Clinical Hospital (Russian Federation)
Alexandr L. Alyanov, Orel State Univ. named after I.S. Turgenev (Russian Federation)
Orel Regional Clinical Hospital (Russian Federation)
Vadim F. Muradyan, Orel Regional Clinical Hospital (Russian Federation)


Published in SPIE Proceedings Vol. 11065:
Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine
Elina A. Genina; Valery V. Tuchin, Editor(s)

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