Share Email Print
cover

Proceedings Paper • new

Laser biosensor based on micromechanical oscillator
Format Member Price Non-Member Price
PDF $17.00 $21.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

We present laser microweight biosensor based on the adaptive holographic interferometer. The sensing element of the sensor is gold coated silicon microcantilever with dimensions of 210×40×5 μm3. Biomolecules of the interest being attached to the cantilever increase its mass which in its turn leads to decreasing the cantilever resonance frequency. The frequency shift of the detected signal is directly proportional to the total mass of adsorbed molecules. Cantilever oscillations are detected by the adaptive holographic interferometer based on two-wave mixing in a photorefractive CdTe crystal. For measuring the concentration of biological molecules dissolved in water the cantilever was installed in a cuvette which contains the solution. In the experiment, adsorbed molecules of BSA (Bovine Serum Albumin) with total mass of 3.1 ng were detected and weighted.

Paper Details

Date Published: 4 January 2019
PDF: 5 pages
Proc. SPIE 11024, Asia-Pacific Conference on Fundamental Problems of Opto- and Microelectronics 2017, 110240G (4 January 2019); doi: 10.1117/12.2519607
Show Author Affiliations
Timofey A. Efimov, Institute for Automation and Control Processes (Russian Federation)
Yuri N. Kulchin, Institute for Automation and Control Processes (Russian Federation)
Far Eastern Federal Univ. (Russian Federation)
Roman V. Romashko, Institute for Automation and Control Processes (Russian Federation)
Far Eastern Federal Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 11024:
Asia-Pacific Conference on Fundamental Problems of Opto- and Microelectronics 2017
Yuri N. Kulchin; Roman V. Romashko; Jyh-Chiang Jiang, Editor(s)

© SPIE. Terms of Use
Back to Top