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Optic nerve head morphometry for glaucoma diagnosis, optimization of clinical measurement strategy
Author(s): Per G. Söderberg; Zhaohua Yu; Camilla Sandberg Melin
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Paper Abstract

The present study aimed to develop a strategy for evaluation of instant PIMD-2π measurements as a basis for clinical monitoring of glaucoma. PIMD-2π is a morphometric measure of the waist of the nerve fiber layer at the optic nerve head (ONH). Clinical measurements of PIMD-2π in patients with early to moderate stage glaucoma demonstrated a high variability among subjects. The high variability among subjects renders comparison of instant PIMD-2π measurements to tolerance limits for normality derived from a normative database inefficient. It is suggested to instead compare sequential measurements of PIMD-2π within a patient. Initially, the difference between an instant measurement and the average of previous measurements can be compared to tolerance limits for difference between measurements within subject. Once, a potential loss of PIMD-2π is detected, a sufficient number of measurements within a sufficiently wide time interval can be used to estimate the PIMD-2π loss rate with regression and the deviation of the estimated loss rate can be evaluated as a 95 % confidence interval for the loss rate. If the upper confidence limit excludes 0, a significant loss rate has been detected. The currently proposed strategy has the potential to detect glaucoma earlier than the current gold standard, computer perimetry, with less inconvenience for the patient.

Paper Details

Date Published: 28 February 2019
PDF: 7 pages
Proc. SPIE 10858, Ophthalmic Technologies XXIX, 108581C (28 February 2019); doi: 10.1117/12.2516319
Show Author Affiliations
Per G. Söderberg, Uppsala Univ. Hospital (Sweden)
Zhaohua Yu, Uppsala Univ. Hospital (Sweden)
Camilla Sandberg Melin, Uppsala Univ. Hospital (Sweden)
Gävle Regional Hospital (Sweden)


Published in SPIE Proceedings Vol. 10858:
Ophthalmic Technologies XXIX
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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