Share Email Print
cover

Proceedings Paper • new

Investigation of electrochemical and mechanical coupling effects of micromotion in neural sensing
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Implanted neural sensing is important to unravel the complexity of neuronal circuitries and understand brain function. Implanted neural devices can capture neurochemical signals in the brain real time. During chronic implantation, micromotion between the neural implant and brain tissue is considered as one of key drivers for immune response and astroglial sheath formation around implants. Therefore, micromotion during in-vivo experiments interfere electrochemical sensing signals and longevity in the brain. This research presents experimental design and results of electrochemical and mechanical coupling of micromotion in a brain-like phantom simulating the brain. A piezoelectric actuator was used to generate motion of an electrode implanted in a phantom while applying potentials for cyclic voltammetry. Electrochemical signal analysis of neurotransmitter sensing was performed to identify motional effects varying experimental conditions such as the frequency and amplitude of mechanical motion, and the chemical and mechanical properties of the brain-like phantom changing the concentration of gelatin. The mechanical effect on neural sensing was also analyzed using DFT. We also introduced a computational model of micromotion in the brain to simulate and analyze mechanical effects on electrochemical neural sensing. The experiment and simulation results show mechanical motion affects the current level in the redox peaks of CV the most, and also shifts the peak voltages.

Paper Details

Date Published: 27 March 2019
PDF: 7 pages
Proc. SPIE 10969, Nano-, Bio-, Info-Tech Sensors and 3D Systems III, 1096908 (27 March 2019); doi: 10.1117/12.2513913
Show Author Affiliations
Seonhye Han, Norfolk State Univ. (United States)
Jisuk Kang, Pusan National Univ. (Korea, Republic of)
Junhyun Kim, Pusan National Univ. (Korea, Republic of)
Myung Yung Jeong, Pusan National Univ. (Korea, Republic of)
Hargsoon Yoon, Norfolk State Univ. (United States)


Published in SPIE Proceedings Vol. 10969:
Nano-, Bio-, Info-Tech Sensors and 3D Systems III
Jaehwan Kim, Editor(s)

© SPIE. Terms of Use
Back to Top