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Multifocal photoacoustic microscopy through an ergodic relay (Conference Presentation)
Author(s): Yang Li; Terence T. W. Wong; Junhui Shi; Hsun-Chia Hsu; Lihong V. Wang
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Paper Abstract

To date, most optical-resolution photoacoustic microscopy (OR-PAM) systems rely on mechanical scanning with confocally aligned optical excitation and ultrasonic detection. As a result, the imaging speed of these systems is limited by the scanning speed. Although several multifocal OR-PA computed tomography (MFOR-PACT) systems had been developed to address this limitation, they were hindered by the complex design in a constrained physical space. Here, we present a two-dimensional (2D) MFOR-PAM system based on a 2D microlens array and an acoustic ergodic relay. This system is able to detect PA signals generated from 400 optical foci in parallel with a single-element transducer, and then raster scan the optical foci patterns to form an image. This system has improved the imaging resolution of a conventional photoacoustic ergodic relay system from 220 μm to 13 μm. Moreover, this system has reduced the imaging time of a conventional OR-PAM system at the same resolution and laser repetition rate by 400 times. We demonstrated the ability of the system with both in vitro and in vivo experiments.

Paper Details

Date Published: 4 March 2019
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Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 108781C (4 March 2019); doi: 10.1117/12.2513502
Show Author Affiliations
Yang Li, California Institute of Technology (United States)
Terence T. W. Wong, Caltech (United States)
Junhui Shi, Caltech (United States)
Hsun-Chia Hsu, Caltech (United States)
Lihong V. Wang, Caltech (United States)


Published in SPIE Proceedings Vol. 10878:
Photons Plus Ultrasound: Imaging and Sensing 2019
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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