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Alzheimer’s disease: label-free fluorescence shows increases in indoleamine 2,3-dioxygenase (IDO) or tryptophan 2,3-dioxygenase (TDO) activity in affected areas of the brain
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Paper Abstract

Abnormal tryptophan metabolism is a major factor in Alzheimer’s disease. Thus, understanding the role of indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO), enzymes that causes increased tryptophan metabolism down the kynurenine pathway, is crucial. Tissue samples from the hippocampus, Brodmann’s area 9 (BA 9) and Brodmann’s area 17 (BA 17) from Alzheimer’s patients, from patients with psychosis and from age-matched, normal controls (total of 47 samples) were studied. An update on the optical properties of Alzheimer’s tissues, utilizing tryptophan/kynurenine ratios, is reported. Ratios of tryptophan/kynurenine were decreased in the hippocampus and BA 9 in patients with Alzheimer’s, consistent with increased neuroinflammation and IDO and/or TDO activity in these areas.

Paper Details

Date Published: 4 March 2019
PDF: 4 pages
Proc. SPIE 10873, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 108731C (4 March 2019); doi: 10.1117/12.2513384
Show Author Affiliations
Laura A. Sordillo, The City College of New York (United States)
Lin Zhang, The City College of New York (United States)
Peter P. Sordillo, The City College of New York (United States)
Lenox Hill Hospital (United States)
Robert R. Alfano, The City College of New York (United States)


Published in SPIE Proceedings Vol. 10873:
Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos; Angela B. Seddon, Editor(s)

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