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Bioessential chalcogenides and immunological applications: an in vitro exploration of Selenium nanoparticles as potential carriers and therapeutic agents (Conference Presentation)
Author(s): Brandy Vincent; Chrismond Smith; Jonathan Mendoza; Ashley Tran; Justine Mendez; Rosemary Robledo; Kelly L. Nash
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Paper Abstract

In recent years, bioessential element-based chalcogenides, namely Selenium (Se) and Tellurium (Te), have established noted fundamentals as metal-based protective agents. In relation to anti-cancer therapeutics, Se in particular exhibits promising characteristics as potentially effective treatment alternatives due to its notoriety as a highly selective, drug-coordinating element. In addition to their competitive clinical resume, Se nanoparticles packaged as chalcogenides are believed to support anti-inflammatory, antimicrobial and antifungal efforts. Though more is needed to understand the biological effect these materials play within the body, studies postulate that there is significant potential for Se based nanoalloys. Partnering Se with elemental neighbor Te, SexTel-x, these alloys function as target mediators. They are believed to sustain cell viability ARPE-19 cells while initiating apoptotic effects on MDA-MB-453 cancer cells, along with promoting the reduction of reactive oxygen species (ROS) activity. Lastly, cellular integrity is maintained by the lack of DNA fragmentation within normal cells, further supporting the efforts of employing SexTel-x alloys as potential anti-cancer agents. Ultimately, this research will serve as fundamental currency marketing SexTel-x nanoalloys as synergistically compliant anti-inflammatory, anti-cancer therapeutic agents, priming the tone for treatment efficacy.

Paper Details

Date Published: 13 March 2019
Proc. SPIE 10892, Colloidal Nanoparticles for Biomedical Applications XIV, 108920S (13 March 2019); doi: 10.1117/12.2513343
Show Author Affiliations
Brandy Vincent, The Univ. of Texas at San Antonio (United States)
Chrismond Smith, The Univ. of Texas at San Antonio (United States)
Jonathan Mendoza, The Univ. of Texas at San Antonio (United States)
Ashley Tran, The Univ. of Texas at San Antonio (United States)
Justine Mendez, Univ. de las Americas Puebla (Mexico)
Rosemary Robledo, The Univ. of Texas at San Antonio (United States)
Kelly L. Nash, The Univ. of Texas at San Antonio (United States)

Published in SPIE Proceedings Vol. 10892:
Colloidal Nanoparticles for Biomedical Applications XIV
Marek Osiński; Wolfgang J. Parak, Editor(s)

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