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Fiber-optic middle infrared evanescent wave spectroscopy for early detection of melanoma
Author(s): Svetlana Basov; Max Platkov; Ilan Goldberg; Yair Dankner; Marcelo Weinstein; Andrey Goryachev; Yosef Raichlin; Eli Sprecher; Abraham Katzir
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Paper Abstract

Melanoma is responsible for most of the fatalities from skin cancer diseases. Yet, there is no reliable method for a noninvasive early detection of skin cancers. We developed a Fiber-optic Evanescent wave Spectroscopy (FEWS) method based on a Fourier Transform Mid-IR (FTIR) spectrometer and on U shaped silver halide (AgClBr) fibers that are highly transparent in the mid-IR. We measured suspicious lesions on patients, before their excision. The central part of the bent fiber touched the lesion and the mid-IR absorption of this area was measured in situ and in real time. As a background, the same measurement was performed on healthy nearby skin. All discomfort to the patient was avoided. The lesions were then examined by conventional means. Histopathology revealed 5 melanoma tumors out of 90 patients and clear and repeating spectral differences between background and lesion are seen in all patients. We continue to accumulate spectral data of melanoma and of other pathologies, for better statistics and for characterization of other types of skin cancer. It is hoped that this non-invasive method for an early detection and diagnosis of skin cancer will replace biopsy and revolutionize this field.

Paper Details

Date Published: 14 March 2019
PDF: 7 pages
Proc. SPIE 10872, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX, 108720Y (14 March 2019); doi: 10.1117/12.2513312
Show Author Affiliations
Svetlana Basov, Tel-Aviv Univ. (Israel)
Max Platkov, Nuclear Research Ctr. Negev (Israel)
Ilan Goldberg, Tel-Aviv Sorasky Medical Ctr. (Israel)
Yair Dankner, Shenkar College of Engineering and Design (Israel)
Marcelo Weinstein, Nuclear Research Ctr. Negev (Israel)
Andrey Goryachev, Ariel Univ. (Israel)
Yosef Raichlin, Ariel Univ. (Israel)
Eli Sprecher, Tel-Aviv Sorasky Medical Ctr. (Israel)
Abraham Katzir, Tel Aviv Univ. (Israel)

Published in SPIE Proceedings Vol. 10872:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX
Israel Gannot, Editor(s)

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