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Characterization of lymph node optical properties for phantom fabrication
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Paper Abstract

Sentinel lymph node biopsy is a primary mean of staging cancer; however, the time-intensive nature of standard pathology limits the volume of the node that can be assessed. As a result, micrometastases can be missed, which have been shown to affect treatment decisions and therefore clinical outcomes. Optical imaging offers a potential solution for improved sensitivity and larger tissue evaluation, but an understanding of optical properties is necessary because of the high scattering nature of biological tissue. Here, time-domain optical imaging and measures of transmittance are used to characterize the optical properties of porcine lymph nodes at 685 nm and 780 nm. Results demonstrated values comparable to that of other soft biological tissue (685 nm: μa = 0.09 ± 0.01cm-1 , μs’ = 2.60 ± 0.42 cm-1 , g = 0.95; 780 nm: μa = 0.24 ± 0.10cm-1 , μs’ = 3.35 ± 0.14 cm-1 , g = 0.92). Based on these coefficients, optical properties of TiO2 were investigated so that a protocol to fabricate a lymph node tissue-mimicking phantom could be defined.

Paper Details

Date Published: 26 February 2019
PDF: 6 pages
Proc. SPIE 10868, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII, 1086813 (26 February 2019); doi: 10.1117/12.2513245
Show Author Affiliations
Veronica C. Torres, Illinois Institute of Technology (United States)
Todd Wilson, Illinois Institute of Technology (United States)
Chengyue Li, Illinois Institute of Technology (United States)
Lagnojita Sinha, Illinois Institute of Technology (United States)
Jovan G. Brankov, Illinois Institute of Technology (United States)
Kenneth M. Tichauer, Illinois Institute of Technology (United States)


Published in SPIE Proceedings Vol. 10868:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII
Anita Mahadevan-Jansen, Editor(s)

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