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Pharmacokinetic biodistribution assessment of Phosphorescent sensor, PtG4 Oxyphor in mice for optimization of in vivo oxygenation imaging
Author(s): Mengyu Jia; Jennifer R. Shell; Xu Cao; Jason R. Gunn; Sergei Vinogradov; Brian W. Pogue
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Paper Abstract

Luminescence molecular tomography with Cherenkov excitation offers the ability to non-invasively image and quantify temporal changes in fluorescence throughout the body, and then further realize tumor localization. This can be done in radiotherapy to determine the response to treatment in fractionated therapy. To obtain high signal-to-background or signal-to-noise ratio measurement, it is critical to know the best post time point of in-vivo agent-based molecular imaging, which could account on a high signal ratio of target to skin (TSR). For this purpose, ex-vivo murine experiments were performed to quantify the biokinetics and biodistribution of the major organs, plasma, tumor, and skin.

Paper Details

Date Published: 8 April 2019
PDF: 1 pages
Proc. SPIE 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V, 108621H (8 April 2019); doi: 10.1117/12.2513220
Show Author Affiliations
Mengyu Jia, Stanford Univ. (United States)
Jennifer R. Shell, Dartmouth College (United States)
Xu Cao, Dartmouth College (United States)
Jason R. Gunn, Dartmouth College (United States)
Sergei Vinogradov, Perelman School of Medicine (United States)
Brian W. Pogue, Dartmouth College (United States)


Published in SPIE Proceedings Vol. 10862:
Molecular-Guided Surgery: Molecules, Devices, and Applications V
Brian W. Pogue; Sylvain Gioux, Editor(s)

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