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Analysis of cumulative surface dose based on Cherenkov imaging of Total Skin Electron Therapy (TSET)
Author(s): Heather Petroccia; Tianshun Miao; Amit Maity; Yihong Ong; Yihua Zhu; Petr Bruza; Brian W. Pogue; John Plastaras; Timothy C. Zhu
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Paper Abstract

Total Skin Electron Therapy (TSET) utilizes high-energy electrons to treat cancers on the entire body surface. The otherwise invisible radiation beam can be observed via the optical Cherenkov photons emitted from interaction between the high-energy electron beam and tissue. Cherenkov emission is used to evaluate the dose uniformity on the surface of the patient in real-time. We have utilized a structured light sensor to determine the surface contour of each patient. Each patient was also monitored during TSET via in-vivo detectors (IVD) and/or scintillating discs in nine locations. The Cherenkov image is converted to dose distribution after a two-dimensional perspective geometry correction and the IVD measured dose at umbilicus. Cumulative dose on patient surface is obtained by projecting the two-dimensional dose distribution onto a cylindrical geometry representing the patient anatomic geometry. Patients undergoing TSET in various conditions (whole body and half body) were imaged and analysed, and the cumulative dose based on Cherenkov imaging was evaluated on various patients.

Paper Details

Date Published: 28 February 2019
PDF: 21 pages
Proc. SPIE 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII, 108600E (28 February 2019); doi: 10.1117/12.2513186
Show Author Affiliations
Heather Petroccia, Univ. of Pennslyvania (United States)
Tianshun Miao, Dartmouth College (United States)
Amit Maity, Univ. of Pennslyvania (United States)
Yihong Ong, Univ. of Pennslyvania (United States)
Yihua Zhu, Univ. of Pennsylvania (United States)
Petr Bruza, Dartmouth College (United States)
Brian W. Pogue, Dartmouth College (United States)
John Plastaras, Univ. of Pennslyvania (United States)
Timothy C. Zhu, Univ. of Pennslyvania (United States)

Published in SPIE Proceedings Vol. 10860:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII
David H. Kessel; Tayyaba Hasan, Editor(s)

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