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Automated signal drift and global fluctuation removal from 4D fMRI data based on principal component analysis as a major preprocessing step for fMRI data analysis
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Paper Abstract

Temporal signal drift is one of the significant artifacts in functional Magnetic Resonance Imaging (fMRI) data that is not given as much attention as motion or physiological artifacts. However, signal drift if not accounted for, can introduce spurious correlation between different regions in resting state fMRI data. Hence detection and removal of signal drift is an important preprocessing step in fMRI data analysis. Here we propose an automated data driven approach that makes use of Principal Component Analysis (PCA) to eliminate not only low frequency signal drift but also spontaneous high frequency global signal fluctuations. This approach is also able to identify the most dominant component for each voxel separately. For task fMRI, this can help us identify regions that respond in a time locked manner to the experiment paradigm. Such regions can be thought of as activation regions. The dominant principal components corresponding to such regions can also be used to investigate intra-region Hemodynamic Response (HR) variability within subjects and across subjects.

Paper Details

Date Published: 15 March 2019
PDF: 9 pages
Proc. SPIE 10953, Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging, 109531E (15 March 2019); doi: 10.1117/12.2512968
Show Author Affiliations
Harshit S. Parmar, Texas Tech Univ. (United States)
Brian Nutter, Texas Tech Univ. (United States)
Rodney Long, U.S. National Library of Medicine (United States)
Sameer K. Antani, U.S. National Library of Medicine (United States)
Sunanda Mitra, Texas Tech Univ. (United States)


Published in SPIE Proceedings Vol. 10953:
Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging
Barjor Gimi; Andrzej Krol, Editor(s)

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