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Learning-based automatic segmentation on arteriovenous malformations from contract-enhanced CT images
Author(s): Tonghe Wang; Yang Lei; Ghazal Shafai-Erfani; Xiaojun Jiang; Xue Dong; Jun Zhou; Tian Liu; Walter J. Curran; Xiaofeng Yang; Hui-Kuo Shu
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Paper Abstract

We propose a learning-based method to automatically segment arteriovenous malformations (AVM) target volume from computed tomography (CT) in stereotactic radiosurgery (SRS). A deeply supervised 3D V-Net is introduced to enable end-to-end segmentation. Deep supervision mechanism is integrated into the hidden layers to overcome the optimization difficulties when training such a network with limited training data. The probability map of new AVM contour is generated by the well-trained network. To evaluate the proposed method, we retrospectively investigate 30 AVM patients treated by SRS. For each patient, both digital subtraction angiography (DSA) and CT with contrast had been acquired. Using our proposed method, the AVM contours are generated solely based on contrast CT images, and are compared with the AVM contours delineated from DSA by physicians as ground truth. The average centroid distance, volume difference and DSC value among all 30 patients are 0.83±0.91mm, -0.01±0.79 and 0.84±0.09, which indicates that the proposed method is able to generate AVM target contour with around 1mm error in displacement, 1cc error in volume size and 84% overlapping compared with ground truth. The proposed method has great potential in eliminating DSA acquisition and developing a solely CT-based treatment planning workflow for AVM SRS treatment.

Paper Details

Date Published: 13 March 2019
PDF: 7 pages
Proc. SPIE 10950, Medical Imaging 2019: Computer-Aided Diagnosis, 109504D (13 March 2019); doi: 10.1117/12.2512553
Show Author Affiliations
Tonghe Wang, Emory Univ. (United States)
Yang Lei, Emory Univ. (United States)
Ghazal Shafai-Erfani, Emory Univ. (United States)
Xiaojun Jiang, Emory Univ. (United States)
Xue Dong, Emory Univ. (United States)
Jun Zhou, Emory Univ. (United States)
Tian Liu, Emory Univ. (United States)
Walter J. Curran, Emory Univ. (United States)
Xiaofeng Yang, Emory Univ. (United States)
Hui-Kuo Shu, Emory Univ. (United States)


Published in SPIE Proceedings Vol. 10950:
Medical Imaging 2019: Computer-Aided Diagnosis
Kensaku Mori; Horst K. Hahn, Editor(s)

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