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Automatic marker-free target positioning and tracking for image-guided radiotherapy and interventions
Author(s): Wei Zhao; Liyue Shen; Yan Wu; Bin Han; Yong Yang; Lei Xing
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Paper Abstract

Current image-guided prostate radiotherapy often relies on the use of implanted fiducial markers (FMs) or transducers for target localization. Fiducial or transducer insertion requires an invasive procedure that adds cost and risks for bleeding, infection and discomfort to some patients. We are developing a novel markerless prostate localization strategy using a pre-trained deep learning model to interpret routine projection kV X-ray images without the need for daily cone-beam computed tomography (CBCT). A deep learning model was first trained by using several thousand annotated projection X-ray images. The trained model is capable of identifying the location of the prostate target for a given input X-ray projection image. To assess the accuracy of the approach, three patients with prostate cancer received volumetric modulated arc therapy (VMAT) were retrospectively studied. The results obtained by using the deep learning model and the actual position of the prostate were compared quantitatively. The deviations between the target positions obtained by the deep learning model and the corresponding annotations ranged from 1.66 mm to 2.77 mm for anterior-posterior (AP) direction, and from 1.15 mm to 2.88 mm for lateral direction. Target position provided by deep learning model for the kV images acquired using OBI is found to be consistent that derived from the implanted FMs. This study demonstrates, for the first time, that highly accurate markerless prostate localization based on deep learning is achievable. The strategy provides a clinically valuable solution to daily patient positioning and real-time target tracking for image-guided radiotherapy (IGRT) and interventions.

Paper Details

Date Published: 8 March 2019
PDF: 8 pages
Proc. SPIE 10951, Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling, 109510B (8 March 2019); doi: 10.1117/12.2512166
Show Author Affiliations
Wei Zhao, Stanford Univ. (United States)
Liyue Shen, Stanford Univ. (United States)
Yan Wu, Stanford Univ. (United States)
Bin Han, Stanford Univ. (United States)
Yong Yang, Stanford Univ. (United States)
Lei Xing, Stanford Univ. (United States)


Published in SPIE Proceedings Vol. 10951:
Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling
Baowei Fei; Cristian A. Linte, Editor(s)

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