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Evaluation of U-net segmentation models for infarct volume measurement in acute ischemic stroke: comparison with fixed ADC threshold-based methods
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Paper Abstract

Ischemic stroke volume is a strong predictor of functional outcome and may play a role in decision making of reperfusion therapy in the late time window (< 6hr of stroke onset to MRI time) when it is obtained along with penumbra volume. Automatic diffusion lesion segmentation can be performed using a commercial software package and is typically based on a fixed apparent diffusion coefficient (ADC) threshold. ADC values alone may not be guaranteed to be highly accurate in the identification of diffusion lesions. Deep learning has the potential to improve the accuracy of diffusion lesion segmentation, provided that a large set of correctly labeled lesion mask data is used for training. The purpose of this study is to evaluate deep learning-based segmentation methods and compare them with three fixed ADC threshold-based methods. U-net was adopted to train a segmentation model. Two U-net models were developed: a model “U-net (DWI+ADC)” trained from DWI and ADC data, and a model “U-net (DWI)” trained from DWI data only. 296 subjects were used for training, and 134 subjects were used for testing. An expert neurologist manually delineated infarct masks on DWI, which served as ground-truth reference. Lesion volume measurements from the two U-net methods and three fixed ADC threshold-based methods were compared against lesion volume measurements from manual segmentation. In testing, the “U-net (DWI+ADC)” method outperformed other methods in lesion volume measurement, with the smallest root-mean-square error of 2.96 ml and the highest Pearson correlation coefficient of 0.997. The proposed method has the potential to automatically measure diffusion lesion volume in a fast and accurate manner, in patients with acute ischemic stroke.

Paper Details

Date Published: 13 March 2019
PDF: 6 pages
Proc. SPIE 10950, Medical Imaging 2019: Computer-Aided Diagnosis, 109502D (13 March 2019); doi: 10.1117/12.2512124
Show Author Affiliations
Yoon-Chul Kim, Sungkyunkwan Univ. (Korea, Republic of)
Ji-Eun Lee, SAMSUNG Medical Ctr. (Korea, Republic of)
Inwu Yu, SAMSUNG Medical Ctr. (Korea, Republic of)
In-Young Baek, SAMSUNG Medical Ctr. (Korea, Republic of)
Han-Gil Jeong, Seoul National Univ. Budang Hospital (Korea, Republic of)
Beom-Joon Kim, Seoul National Univ. Budang Hospital (Korea, Republic of)
Joon-Kyung Seong, Korea Univ. (Korea, Republic of)
Jong-Won Chung, SAMSUNG Medical Ctr. (Korea, Republic of)
Oh Young Bang, SAMSUNG Medical Ctr. (Korea, Republic of)
Woo-Keun Seo, SAMSUNG Medical Ctr. (Korea, Republic of)

Published in SPIE Proceedings Vol. 10950:
Medical Imaging 2019: Computer-Aided Diagnosis
Kensaku Mori; Horst K. Hahn, Editor(s)

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