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Ultraviolet hyperspectral interferometric microscopy
Author(s): Francisco E. Robles
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Paper Abstract

Ultraviolet (UV) spectroscopy is a powerful tool for quantitative biochemical analysis, but its application to molecular imaging and microscopy has been limited. Here we describe our recent work on ultraviolet hyperspectral interferometric (UHI) microscopy, which leverages coherent detection of optical fields to overcome significant challenges associated with UV spectroscopy when applied to molecular imaging. We demonstrate that this method enables quantitative spectral analysis of important endogenous biomolecules with subcellular spatial resolution and sensitivity to nanometer-scaled structures for label-free molecular imaging of live cells.

Paper Details

Date Published: 4 March 2019
PDF: 6 pages
Proc. SPIE 10888, Biophysics, Biology and Biophotonics IV: the Crossroads, 108880A (4 March 2019); doi: 10.1117/12.2511967
Show Author Affiliations
Francisco E. Robles, Georgia Institute of Technology & Emory Univ. School of Medicine (United States)

Published in SPIE Proceedings Vol. 10888:
Biophysics, Biology and Biophotonics IV: the Crossroads
Adam Wax; Vadim Backman, Editor(s)

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