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Combining ionising radiation with nanoconstructs: towards new options in cancer therapy (Conference Presentation)
Author(s): Ewa M. Goldys; Sandhya Clement; Wei Deng
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Paper Abstract

Chemo- and/or radiotherapy remain treatment standards for cancer. Clinical challenges including poor tumour specificity and cause dose-dependent side effects. The proposed new treatment modality combining radiation and radiation-triggered nanoconstructs can selectively target and efficiently destroy deep-seated tumours. To achieve this, we combined existing clinical techniques used in cancer treatment–X-ray radiation and other treatment modalities including chemotherapy and photodynamic therapy by using various nanoparticles which we successfully developed. They included scintillator nanoparticles (CeF3), Au nanoparticles, Poly Lactic-co-Glycolic Acid (PLGA) polymer and liposome nanoparticles. A photosensitive molecule, verteporfin was either conjugated (in the case of CeF3) or loaded inside the nanoparticles (in the case of PLGA polymer and liposomes). Their unique combination enables effective ablation of cancer cells in vitro and control of tumour growth in vivo at a low X-ray dose, which was conclusively demonstrated by our recent work.

Paper Details

Date Published: 4 March 2019
Proc. SPIE 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V, 1086215 (4 March 2019); doi: 10.1117/12.2511905
Show Author Affiliations
Ewa M. Goldys, The Univ. of New South Wales (Australia)
Sandhya Clement, The Univ. of New South Wales (Australia)
Wei Deng, The Univ. of New South Wales (Australia)

Published in SPIE Proceedings Vol. 10862:
Molecular-Guided Surgery: Molecules, Devices, and Applications V
Brian W. Pogue; Sylvain Gioux, Editor(s)

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