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Device for silent substitution excitation of melanopsin for human eye
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Paper Abstract

Research in neurobiology has identified a new ocular photoreceptor (melanopsin or ipRGC) which mediates a variety of light-based, non-visual effects on human physiology. One way to isolate the stimulation of ipRGCs is the silent substitution technique. We have built a Maxwellian view device capable of 85% ipRGCs contrast excitation with a large FOV (52o). Four modulated LED light sources, illuminate a diffusing sphere, which exit aperture is imaged into the pupil of the eye. A camera with a 900 nm illumination capture the pupil. Without luminance changes (510±2 lm/m2), we increased ipRGC excitation from low to high level on three subjects. We observed a pupil constriction increasing with the ipRGC contrast. This suggests that we excite melanopsin silently. However, further experiments with electrophysiological and pupil recording needs to be done to completely validate our silent substitution device.

Paper Details

Date Published: 28 February 2019
PDF: 7 pages
Proc. SPIE 10858, Ophthalmic Technologies XXIX, 1085813 (28 February 2019); doi: 10.1117/12.2511654
Show Author Affiliations
Sergiu Agrici, Univ. degli Studi di Modena e Reggio Emilia (Italy)
Univ. of Applied Sciences of Western Switzerland (Switzerland)
Frederic Truffer, Haute Ecole Spécialisée de Suisse Occidentale (Switzerland)
Chirojean Balachandran, Ecole Nationale Superieure de l'Electronique et de ses Applications (France)
Aki Kawasaki, Fondation Asile des Aveugles (Swaziland)
Martial Geiser, Haute Ecole Spécialisée de Suisse Occidentale (Switzerland)


Published in SPIE Proceedings Vol. 10858:
Ophthalmic Technologies XXIX
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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