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Correcting Cherenkov images for large-scale tissue-optical property attenuation using SFDI and patterned light reflectance for quantitative dosimetry
Author(s): Rachael L. Hachadorian; Petr Bruza; Michael Jermyn; Lesley A. Jarvis; David Gladstone; Brian W. Pogue
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Paper Abstract

Tissue optical properties attenuate a substantial percentage of the optical light being detected during real-time Cherenkov acquisition, which distortsthe signal linearity previously observed with absorbed dose in homogeneous media. This hinders progression toward establishing quantitative dosimetry using Cherenkov imaging in vivo. By spectrally weighting effective attenuation (μeff) maps generated by multi-wavelength Spatial Frequency Domain Imaging (SFDI), it became possible to more successfully correct clinical Cherenkov images for areolar attenuation (6% difference, as compared to the treatment plan) compared to selecting one wavelength channel in a previous study (41% difference). Additionally, using a reflected light-based patient positioning system, we were able to characterize and correct for gross tissue optical properties in patient images, namely for large-scale surface and subsurface attenuation. While the use of wide-field SFDI enabled pixel-bypixel corrections, the benefit of using an integrated, light-based system for reflectance-based corrections negates the use of an external imaging system, which substantially smooths workflow.

Paper Details

Date Published: 1 March 2019
PDF: 9 pages
Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 1087414 (1 March 2019); doi: 10.1117/12.2511111
Show Author Affiliations
Rachael L. Hachadorian, Thayer School of Engineering at Dartmouth (United States)
Petr Bruza, Thayer School of Engineering at Dartmouth (United States)
Michael Jermyn, Thayer School of Engineering at Dartmouth (United States)
DoseOptics, LLC (United States)
Lesley A. Jarvis, Geisel School of Medicine, Dartmouth College (United States)
Dartmouth-Hitchcock Medical Ctr. (United States)
Norris Cotton Cancer Ctr. (United States)
David Gladstone, Dartmouth Hitchcock Medical Ctr. (United States)
Thayer School of Engineering at Dartmouth (United States)
Norris Cotton Cancer Ctr. (United States)
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
DoseOptics, LLC (United States)
Dartmouth-Hitchcock Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 10874:
Optical Tomography and Spectroscopy of Tissue XIII
Sergio Fantini; Bruce J. Tromberg; Eva Marie Sevick-Muraca; Paola Taroni, Editor(s)

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