Share Email Print
cover

Proceedings Paper • new

Validation of a Monte Carlo modeling based dosimetry of extraoral photobiomodulation (Conference Presentation)
Author(s): Anna N. Yaroslavsky; Wendy B. London; Christine N. Duncan; Wayne J. Selting; James D. Carroll; Amy F. Juliano; Stephen T. Sonis; Ather Adnan; Nathaniel S. Treister

Paper Abstract

Background and Objective: Extraoral photobiomodulation therapy (PBM Therapy) is a novel treatment for the prevention of oral mucositis, a painful side effect of myeloablative chemotherapy, and there are no standardized dosimetry protocols for this procedure. We used Monte Carlo modeling to determine optimal parameters for a safe and efficacious treatment. The objective of this work was to experimentally validate the results of Monte Carlo dose modeling of extraoral PBM Therapy by conducting a pilot validation study. Methods: Light penetration through the right cheek of four volunteers with skin types I-VI was measured. A 69-LED array with an area of 31.2 cm2 was applied to the external cheek delivering 26 mW/cm2 at 850 nm to the surface. Power density at the intraoral mucosa was recorded under a controlled pressure of 18gm/cm2. To obtain morphological information, we acquired T1 weighted MRI images of the volunteers' heads and measured the thickness of the skin, fat, and muscle layers of the cheek of each volunteer. These anatomical data together with the optical properties from the literature were used to simulate light propagation through the right cheek. Results and Conclusions: Our study revealed that experimental and simulation results were in good agreement for all 4 subjects. The difference between the mean values of the measured fluence rates was within 16% from the respective fluence rates obtained using Monte Carlo simulations. We confirmed that there was no temperature increase due to illumination. Monte Carlo modeling is a robust and reliable method for PBM Therapy light dosimetry.

Paper Details

Date Published: 13 March 2019
PDF
Proc. SPIE 10861, Mechanisms of Photobiomodulation Therapy XIV, 1086104 (13 March 2019); doi: 10.1117/12.2510986
Show Author Affiliations
Anna N. Yaroslavsky, Univ. of Massachusetts Lowell (United States)
Massachusetts General Hospital (United States)
Wendy B. London, Dana-Farber Cancer Institute, Boston Children's Hospital (United States)
Harvard Medical School (United States)
Christine N. Duncan, Dana-Farber Cancer Institute, Boston Children's Hospital (United States)
Harvard Medical School (United States)
Wayne J. Selting, Univ. degli Studi di Genova (Italy)
James D. Carroll, THOR Photomedicine Ltd. (United Kingdom)
Amy F. Juliano, Massachusetts Eye and Ear (United States)
Harvard Medical School (United States)
Stephen T. Sonis, Biomodels, LLC (United States)
Brigham and Women's Hospital (United States)
Harvard School of Dental Medicine (United States)
Ather Adnan, Brigham and Women's Hospital (United States)
Nathaniel S. Treister, Brigham and Women's Hospital (United States)
Harvard School of Dental Medicine (United States)


Published in SPIE Proceedings Vol. 10861:
Mechanisms of Photobiomodulation Therapy XIV
Michael R. Hamblin; James D. Carroll; Praveen Arany, Editor(s)

© SPIE. Terms of Use
Back to Top