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Magnetic resonance imaging thermometry for laser immunotherapy in orthotopic pancreatic cancer
Author(s): Austin Doughty; Yong Li M.D.; Meng Wang; Feifan Zhou; Debra Saunders; Nataliya Smith; Rheal Towner; Wei R. Chen
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Paper Abstract

Laser Immunotherapy is a recently-developed treatment for metastatic cancers that synergistically applies photothermal laser irradiation in conjunction with a local immunoadjuvant to induce a host anti-cancer immune response. We have used laser immunotherapy to treat orthotopic pancreatic tumors in mice. In this study, we used magnetic resonance imaging to guide laser immunotherapy for interstitial treatment of metastatic pancreatic tumors in mice. Furthermore, we used MRI to investigate tumor location, guide laser treatment, and monitor the photothermal effects using proton resonance frequency shift thermometry. Our results indicate that laser immunotherapy could be an effective modality for late-stage pancreatic cancer patients, and that MRI thermometry can effectively monitor treatment for guidance.

Paper Details

Date Published: 7 March 2019
PDF: 5 pages
Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 1087916 (7 March 2019); doi: 10.1117/12.2510969
Show Author Affiliations
Austin Doughty, Univ. of Central Oklahoma (United States)
Yong Li M.D., Univ. of Central Oklahoma (United States)
Tianjin Medical Univ. Cancer Institute and Hospital (China)
Meng Wang, Univ. of Central Oklahoma (United States)
Feifan Zhou, Univ. of Central Oklahoma (United States)
Shenzhen Univ. (China)
Debra Saunders, Oklahoma Medical Research Foundation (United States)
Nataliya Smith, Oklahoma Medical Research Foundation (United States)
Rheal Towner, Oklahoma Medical Research Foundation (United States)
Wei R. Chen, Univ. of Central Oklahoma (United States)


Published in SPIE Proceedings Vol. 10879:
Biophotonics and Immune Responses XIV
Wei R. Chen, Editor(s)

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