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Targeting drug-resistant glioblastoma stem cells using photodynamic therapy (Conference Presentation)
Author(s): Bryan Q. Spring; Kohei Watanabe; Megumi Ichikawa; Srivalleesha Mallidi; Tatsuyuki Matsudaira; Dmitriy Timerman; Hiroaki Wakimoto; Tayyaba Hasan

Paper Abstract

Standard chemoradiation often enriches drug-resistant tumor cell populations that can lead to recurrent and treatment-refractory disease. Preclinical models of glioblastoma brain tumors, for instance, suggest that the cancer stem cell subpopulation becomes enriched and re-populates the tumor milieu following conventional therapies. Here, we show evidence that photodynamic therapy (PDT) is effective against several patient-derived glioblastoma stem cell cultures. Moreover, sub-lethal PDT results in re-sensitization of cancer stem cell phenotypes with induced drug-resistance to chemotherapy.

Paper Details

Date Published: 7 March 2019
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Proc. SPIE 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII, 1086004 (7 March 2019); doi: 10.1117/12.2510962
Show Author Affiliations
Bryan Q. Spring, Northeastern Univ. (United States)
Kohei Watanabe, Wellman Ctr. for Photomedicine (United States)
Canon U.S.A., Inc. (United States)
Megumi Ichikawa, Wellman Ctr. for Photomedicine (United States)
Srivalleesha Mallidi, Wellman Ctr. for Photomedicine (United States)
Tatsuyuki Matsudaira, Wellman Ctr. for Photomedicine (United States)
Dmitriy Timerman, Wellman Ctr. for Photomedicine (United States)
Hiroaki Wakimoto, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Tayyaba Hasan, Wellman Ctr. for Photomedicine (United States)
Massachusetts General Hospital (United States)
Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 10860:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII
David H. Kessel; Tayyaba Hasan, Editor(s)

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