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Mn-doped Zn/S quantum dots as photosensitizers for antimicrobial photodynamic inactivation
Author(s): Chenyu Jiang; Frank Scholle; Reza A. Ghiladi
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Paper Abstract

The survival of pathogens on surfaces is a major contributor to infection transmission, and drives the development of selfsterilizing surfaces. Here, we have investigated if manganese-doped zinc sulfide quantum dots (Mn:ZnS QDs) can be used as photosensitizers for their potential application in surface disinfection via antimicrobial photodynamic inactivation (aPDI). A small library of Mn:ZnS QDs capped with 3-mercaptopropionic acid was synthesized using a hydrothermal approach in which both the amount of manganese (0-30 at.%) and heating period (9 – 20 h) were varied. The resultant Mn:ZnS QDs were shown by transmission electron microscopy to vary in size from 2.6-3.9 Å as a function of heating time, and exhibited a strong emission band at ~598 nm (λex = 325 nm). Upon excitation of 5%-Mn:ZnS QDs at 514 nm, a near-IR emission band attributable to singlet oxygen phosphorescence was observed at 1278 nm, confirming that these QDs may function as photosensitizers via a Type II mechanism. The aPDI efficacy of the Mn:ZnS QDs was evaluated against both Gram-positive [methicillin-resistant S. aureus (MRSA; ATCC-44), vancomycin-resistant E. faecium (VRE; ATCC-2320)], and Gram-negative [multidrug-resistant A. baumannii (MDRAB; ATCC-1605), NDM-1 positive K. pneumoniae (KP; ATCC-2146)] bacteria. Our best results demonstrated detection limit photodynamic inactivation (6 log units reduction) of KP, MDRAB, and MRSA upon illumination (30 min; 65±5 mW/cm2; 400-700 nm), but only a ~1 log unit reduction against VRE. Together with antiviral studies of Zika virus that showed ~3 log units of inactivation, these findings demonstrate the utility of Mn:ZnS QDs as photosensitizers for aPDI.

Paper Details

Date Published: 7 March 2019
PDF: 14 pages
Proc. SPIE 10863, Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases II, 108630Q (7 March 2019); doi: 10.1117/12.2510934
Show Author Affiliations
Chenyu Jiang, North Carolina State Univ. (United States)
Frank Scholle, North Carolina State Univ. (United States)
Reza A. Ghiladi, North Carolina State Univ. (United States)

Published in SPIE Proceedings Vol. 10863:
Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases II
Tianhong Dai; Jürgen Popp; Mei X. Wu, Editor(s)

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