Share Email Print
cover

Proceedings Paper • new

Agent-free high speed localization photoacoustic microscopy
Author(s): Jongbeom Kim; Jin Young Kim; Seungwan Jeon; Jin Woo Baik; Seong Hee Cho; Chulhong Kim
Format Member Price Non-Member Price
PDF $17.00 $21.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Photoacoustic microscopy (PAM) as an emerging microscopy system have shown the capability of anatomical, functional, metabolic and pathological imaging of animals and humans in vivo. However, conventional PAM systems have limited spatial and/or temporal resolutions. Microelectromechanical systems (MEMS) scanners and super-resolution techniques have been used, but the MEMS scanners were unstable and conventional ultra-high resolution imaging methods were slow and/or required exogenous contrast agents. Here, we present an agent-free high speed PAM using a stable commercial scanner (L-PAM) that improves both spatial and temporal resolution concurrently. A B-mode image rate is improved up to a B-mode image rate of 500 Hz with the scanner. By localizing endogenous contrasts, unresolved microvessels in general PAM system are resolved. These enhancements enable the observation of microvasculatures and functional hemodynamics of animals and humans in vivo. This L-PAM enables leading to new studies in a variety of fields including neurology, oncology, pathology, pharmacology, etc.

Paper Details

Date Published: 27 February 2019
PDF: 6 pages
Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 108781B (27 February 2019); doi: 10.1117/12.2510841
Show Author Affiliations
Jongbeom Kim, Pohang Univ. of Science and Technology (Korea, Republic of)
Jin Young Kim, Pohang Univ. of Science and Technology (Korea, Republic of)
Seungwan Jeon, Pohang Univ. of Science and Technology (Korea, Republic of)
Jin Woo Baik, Pohang Univ. of Science and Technology (Korea, Republic of)
Seong Hee Cho, Pohang Univ. of Science and Technology (Korea, Republic of)
Chulhong Kim, Pohang Univ. of Science and Technology (Korea, Republic of)


Published in SPIE Proceedings Vol. 10878:
Photons Plus Ultrasound: Imaging and Sensing 2019
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

© SPIE. Terms of Use
Back to Top