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Optimal NIR and SWIR optical parameters for absorption and SHG detecting deep tissue vessels in intestinal submucosa
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Paper Abstract

In gastrointestinal endoscopic surgery, bleeding from the accidental resection of hidden vessels is a major complication, requiring immediate conversion to open surgery. Methods of visualizing occult vessels have been proposed using the FDA approved fluorescent dye Indocyanine green (ICG), but Native label-free fluorescence of the submucosa—present up till about 886 nm—prevents the use ICG in near-infrared (NIR) window I (700 nm to 900 nm). Instead, absorption imaging is preferred; the darker vessels are visible to 4.5 mm deep. Using data from Raman scattering, absorption, native fluorescence, SHG and the photon excitation fluorescence we investigate the spectral properties and propose optimal parameters for differentiation of blood vessels from surrounding tissue in a variety of tissue types in NIR window II (1000 nm to 1350 nm) and NIR window III (1550 nm to 1900 nm, the “Golden Window”) as a complement to absorption imaging.

Paper Details

Date Published: 11 March 2019
PDF: 7 pages
Proc. SPIE 10873, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 1087319 (11 March 2019); doi: 10.1117/12.2510834
Show Author Affiliations
Shirley Chan, The City College of New York (United States)
Min Jing Zheng, The City College of New York (United States)
Tiffany Chou, The City College of New York (United States)
Stewart Russell, The City College of New York (United States)
Robert R. Alfano, The City College of New York (United States)


Published in SPIE Proceedings Vol. 10873:
Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos; Angela B. Seddon, Editor(s)

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