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Label-free infrared spectroscopic imaging for characterization of necrotic tissue areas on cutaneous squamous cell carcinoma
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Paper Abstract

In this study, FTIR spectroscopy was used to evaluate the overall biochemical status of necrotic tissue areas of cutaneous squamous cell carcinoma chemically-induced on mice. FTIR hyperspectral image collected from specimen showed high correlation with the photomicrograph obtained by light microscopy, in which we were able to identify clusters associated to keratin, necrosis and regions with no tissue. Alterations in the protein content were documented in the necrotic tissue areas, indicating changes on protein conformation.

Paper Details

Date Published: 26 February 2019
PDF: 6 pages
Proc. SPIE 10868, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII, 1086812 (26 February 2019); doi: 10.1117/12.2510711
Show Author Affiliations
Cássio A. Lima, Instituto de Pesquisas Energéticas e Nucleares (Brazil)
Luciana Correa, Univ. de São Paulo (Brazil)
Hugh J. Byrne, Dublin Institute of Technology (Ireland)
Denise M. Zezell, Instituto de Pesquisas Energéticas e Nucleares (Brazil)


Published in SPIE Proceedings Vol. 10868:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII
Anita Mahadevan-Jansen, Editor(s)

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