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Validation of Dosie combined Monte Carlo and photokinetic simulations for the analysis of HPPH-mediated photodynamic therapy on mice
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Paper Abstract

We compare previously reported 2-(1-hexyloxyethyl)-2-divinyl pyropheophorbide (HPPH) mediated photodynamic therapy (PDT) experimental results for singlet oxygen dose on mice with simulations using a new, integrated, hardware and software device, DosieTM, that calculates light transport and photokinetics for PDT. The two sets of results are consistent and validate the use of the device simulations to predict HPPH-mediated PDT results on mice animal studies.

Paper Details

Date Published: 28 February 2019
PDF: 10 pages
Proc. SPIE 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII, 108600N (28 February 2019); doi: 10.1117/12.2510686
Show Author Affiliations
Karl Beeson, Simphotek Inc. (United States)
Evgueni Parilov, Simphotek Inc. (United States)
Mary Potasek, Simphotek Inc. (United States)


Published in SPIE Proceedings Vol. 10860:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII
David H. Kessel; Tayyaba Hasan, Editor(s)

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