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Comparison of detection sensitivity of near infrared (NIR) surgical imaging systems using a connective tissue phantom model
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Paper Abstract

Many tumors for which fluorescence guided surgery (FGS) has been developed are surface tumors, where direct visualization by the surgeon is straightforward. On the other hand, cancers such as soft-tissue sarcomas, are present at a subsurface level. Resection of these sub-surface tumors is performed using ‘wide local excision’ where a single, complete mass is removed with an intact zone of normal tissue (~ 1 cm ‘margin’). We used a phantom model for sarcoma with near infrared fluorophore IRDye800 CW that defined different tissue properties. We compare the detection sensitivity of two commercially available near infrared (NIR) surgical imaging systems, Solaris (Perkin Elmer) and SPY PHI (Novadaq) using the phantom models of sarcoma. We also determine targeted fluorescence signal on both systems for blinded surgical phantom dissection by a surgeon. The fluorescence intensities are higher for Solaris than for SPY-PHI. On average, the fluorescence increased with an increase in intralipid concentration and decreased with an increase in blood concentration. The depth of imaging was higher for Solaris than for SPY PHI. Using the target values, the surgeon successfully dissected all phantoms using Solaris. Using fat phantoms for SPY PHI, the surgeon cut through four out of the total. Further improvement in FGS will improve cancer recurrence and morbidity.

Paper Details

Date Published: 7 March 2019
PDF: 9 pages
Proc. SPIE 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V, 108620Z (7 March 2019); doi: 10.1117/12.2510650
Show Author Affiliations
Hira Shahzad Sardar, Dartmouth College (United States)
Qais Zai, Dartmouth College (United States)
Jason Gunn, Dartmouth College (United States)
Brian Pogue, Dartmouth College (United States)
Keith Paulsen, Dartmouth College (United States)
Kimberley Samkoe, Dartmouth College (United States)
Eric Henderson, Dartmouth-Hitchcock Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 10862:
Molecular-Guided Surgery: Molecules, Devices, and Applications V
Brian W. Pogue; Sylvain Gioux, Editor(s)

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