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In vivo demonstration of real-time oxygen saturation imaging using a portable and affordable LED-based multispectral photoacoustic and ultrasound imaging system
Author(s): Mithun Kuniyil Ajith Singh; Naoto Sato; Fumiyuki Ichihashi; Yoshiyuki Sankai
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Paper Abstract

Photoacoustic imaging is a hybrid medical imaging technique that combines the contrast and spectral sensitivity of optical imaging with resolution and tissue penetration of ultrasound. Due to the difference between the optical absorption spectra of deoxygenated and oxygenated hemoglobin, multispectral photoacoustic imaging holds strong potential in noninvasive local blood oxygen saturation imaging. Oxygen saturation imaging is one of the most promising applications of photoacoustic imaging and has been widely explored in studies related to tumor hypoxia, cancer therapy etc. However, clinical translation of this technology has often been limited by bulky and expensive excitation sources. Recently, we introduced a multi-wavelength real-time LED-based photoacoustic/ultrasound imaging system. In this work, potential of this LED-based system in real-time oxygen saturation imaging is demonstrated using an in vivo measurement on a human volunteer. We used ultra-fast switching two-wavelength LED arrays (750nm/850nm) along with a linear-array 7 MHz US probe for the experiments. 2D PA, US, and oxygen saturation imaging were performed on the index finger of a human volunteer. Results demonstrate that LED-based PA imaging system used in this study is promising for generating 2D/3D oxygen saturation maps along with PA and US images in real-time. We believe that these results will have profound impact in non-invasive blood oxygen saturation imaging and subsequent clinical translation of PA-based oximetry.

Paper Details

Date Published: 27 February 2019
PDF: 4 pages
Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 108785N (27 February 2019); doi: 10.1117/12.2510636
Show Author Affiliations
Mithun Kuniyil Ajith Singh, Cyberdyne, Inc. (Netherlands)
Naoto Sato, Cyberdyne, Inc. (Japan)
Fumiyuki Ichihashi, Cyberdyne, Inc. (Japan)
Yoshiyuki Sankai, Cyberdyne, Inc. (Japan)

Published in SPIE Proceedings Vol. 10878:
Photons Plus Ultrasound: Imaging and Sensing 2019
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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