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Insulin-coated gold nanoparticles as an effective approach for bypassing the blood-brain barrier
Author(s): Oshra Betzer; Malka Shilo; Menachem Motiei; Rachela Popovtzer
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Paper Abstract

A major challenge for treatment of neurodegenerative disorders is the need to overcome the restrictive mechanism of the blood-brain-barrier (BBB) for delivery of therapeutic agents into the brain. Our goal was to develop an efficient nanoparticle-based system with the ability to bypass the BBB by targeting insulin receptors. We demonstrate that insulincoated gold-nanoparticles (INS-GNPs) can serve as an effective endogenous BBB transport system for delivering therapeutics into the brain. We further conducted a quantitative in-vivo investigation of the effect of nanoparticle size (20, 50 and 70nm) on the ability of INS-GNPs to cross the BBB. The most widespread bio-distribution and highest accumulation within the brain (5% of the injected dose) was observed using 20nm INS-GNPs, two hours post-injection. In-vivo CT imaging revealed that particles migrated to specific brain regions, rich in insulin receptors, which are important targets for the treatment of various neurodegenerative disorders. The findings described herein suggest the potential beneficial use of INS-GNPs as nano-vehicles for the transport of drugs through the BBB.

Paper Details

Date Published: 5 March 2019
PDF: 10 pages
Proc. SPIE 10891, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI, 108911H (5 March 2019); doi: 10.1117/12.2510353
Show Author Affiliations
Oshra Betzer, Bar-Ilan Univ. (Israel)
Malka Shilo, Tel Aviv Univ. (Israel)
Menachem Motiei, Bar-Ilan Univ. (Israel)
Rachela Popovtzer, Bar-Ilan Univ. (Israel)

Published in SPIE Proceedings Vol. 10891:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI
Dan V. Nicolau; Dror Fixler; Ewa M. Goldys, Editor(s)

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