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Towards accurate and label-free monitoring of bio-analytes using supercontinuum based multispectral photoacoustic spectroscopy in the extended near-infrared wavelength regime
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Paper Abstract

In this work, we report a cost-effective supercontinuum (SC) laser-based multispectral photoacoustic spectroscopy (MSPAS) system for studying spectral characteristics of various analytes. We demonstrate an in vitro label-free monitoring of the analytes in the extended near-infrared (NIR) (1540–1840 nm) spectral range. We further demonstrate how a simple ratiometric analysis in conjunction with linear regression can be used for accurate prediction of glucose over commonly encountered physiological levels inside the human body (0–400 mg/dL). Looking forward, the proposed SC-based MSPAS system provides a framework for the development of label-free and non-invasive monitoring multiple bio-analytes accurately, with potential translation to clinical in vivo applications.

Paper Details

Date Published: 4 March 2019
PDF: 6 pages
Proc. SPIE 10890, Label-free Biomedical Imaging and Sensing (LBIS) 2019, 108900W (4 March 2019); doi: 10.1117/12.2510284
Show Author Affiliations
Manoj Kumar Dasa, Technical Univ. of Denmark (Denmark)
Christos Markos, Technical Univ. of Denmark (Denmark)
Jakob Janting, Technical Univ. of Denmark (Denmark)
Abubakar I. Adamu, Technical Univ. of Denmark (Denmark)
Patrick Bowen, NKT Photonics A/S (Denmark)
Ole Bang, Technical Univ. of Denmark (Denmark)
NKT Photonics A/S (Denmark)

Published in SPIE Proceedings Vol. 10890:
Label-free Biomedical Imaging and Sensing (LBIS) 2019
Natan T. Shaked; Oliver Hayden, Editor(s)

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