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Innovative and high-performance instrumentation for biomedical Mueller polarimetric imaging in vivo
Author(s): Arvid Lindberg; Jérémy Vizet; Jean Rehbinder; Camille Gennet; Jean-Charles Vanel; Angelo Pierangelo
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Paper Abstract

Mueller Polarimetric Imaging (MPI) showed promising results in biomedical applications, especially for early detection of precancerous lesions on biological tissues. This technique is label-free, non-invasive and can be implemented with a large field of view (up to several cm2) to image wide areas of biological tissues while providing information on its microstructure. The development of innovative (MPI) systems, able to analyze biological tissues in vivo on human patients, remains an instrumental challenge. Our goal is to build miniaturized and compact full-field MPI systems based on Ferroelectric Liquid Crystals (FLCs) capable of performing a multispectral accurate analysis of biological tissues in vivo. In this work, an innovative approach is showed to realize optimized and fast FLCs-based MPI systems able to perform full-field imaging acquisitions in the spectral range between 450 and 700nm with error less than 1% on all the elements of measured Mueller matrices. This system can be accurately calibrated by using the Eigenvalue Calibration Method (ECM) also in presence of high residual instrumental depolarization. This approach enables us to realize compact and reliable MPI systems which can be easily integrated into existing instruments currently used in medical practice.

Paper Details

Date Published: 4 March 2019
PDF: 8 pages
Proc. SPIE 10873, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 108730J (4 March 2019); doi: 10.1117/12.2510232
Show Author Affiliations
Arvid Lindberg, Ecole Polytechnique (France)
Jérémy Vizet, Ecole Polytechnique (France)
Jean Rehbinder, ICube, Univ. de Strasbourg (France)
Camille Gennet, Ecole Polytechnique (France)
Jean-Charles Vanel, Ecole Polytechnique (France)
Angelo Pierangelo, Ecole Polytechnique (France)

Published in SPIE Proceedings Vol. 10873:
Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos; Angela B. Seddon, Editor(s)

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